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1994-10-25
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Document 2985
DOCN M94A2985
TI Intensive chemotherapy and G-CSF in HIV-associated non-Hodgkin's
lymphoma.
DT 9412
AU Oksenhendler E; Dubreull ML; Gerard L; Barateau V; Levy Y; Deforges L;
Ferchal F; Clauvel JP; Hopital Saint-Louis, Paris, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):18 (abstract no. 044B). Unique
Identifier : AIDSLINE ICA10/94369590
AB OBJECTIVE: To evaluate efficacy, safety and virological impact of
intensive chemotherapy associated with G-CSF in HIV-associated NHL.
PATIENTS: 33 HIV+ patients with aggressive NHL and CD4+ cells > or =
100. CDC group IV: 10; mean CD4: 344 (100-910). Burkitt: 16, large cell:
10, immunoblastic: 4, anaplastic: 3; stage IV: 17; marrow+: 7, CNS+: 9.
THERAPY: Week 1,3,5: doxorubicin 75 mg/m2 d1, cyclophosphamide 1,2g/m2
d1, vindesine 2mg/m2 d1&5, bleomycin 10mg d1&5, prednisolone 80mg/m2
d1to5. W 8,10,12: cyclophosphamide 1g/m2 d1, etoposide 200mg/m2 d1&2,
methotrexate 3g/m2 d2+folinic acid. G-CSF 5 micrograms/kg d6to13 at each
cycle. RESULTS: F-up: 14m. Complete remission: 23(70%). Relapse: 2.
Alive in CR: 19; deaths: 14 (12 with NHL); median survival 13,5m.
Dose-Intensity: 88% for doxorubicin, 86% for cyclophosphamide. VIROLOGY:
mean acid-dissociated p24Ag dropped by d6 (-48%, p < .001), remained
stable with G-CSF and reached baseline value at end of therapy.
CONCLUSION: LNHIV-91 regimen+G-CSF is effective and safe in selected
patients with CD4 > or = 100. TABULAR DATA, SEE ABSTRACT VOLUME.
DE Antineoplastic Agents, Combined/ADVERSE EFFECTS/*THERAPEUTIC USE
Bleomycins/ADMINISTRATION & DOSAGE Cyclophosphamide/ADMINISTRATION &
DOSAGE Doxorubicin/ADMINISTRATION & DOSAGE Drug Administration
Schedule Etoposide/ADMINISTRATION & DOSAGE Granulocyte
Colony-Stimulating Factor/*THERAPEUTIC USE Human HIV
Infections/*COMPLICATIONS Leucovorin/ADMINISTRATION & DOSAGE Lymphoma,
AIDS-Related/DRUG THERAPY/*THERAPY Lymphoma, Non-Hodgkin's/DRUG
THERAPY/*THERAPY Methotrexate/ADMINISTRATION & DOSAGE
Vindesine/ADMINISTRATION & DOSAGE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).